Karnozol, norursa and noroleana

extraordinary anticancer and antiparasitic properties of diterpenes and triterpenes contained in rosemary

See other articles

Rosmarinus officinalis L.

Rosmarinus officinalis L. (or Salvia rosmarinus) is the scientific name of rosemary, an evergreen shrub belonging to the Lamiaceae family. It has coniferous, narrow leaves and flowers with a characteristic aromatic scent. It is widely used as a culinary and cosmetic plant, and also has traditional uses in folk medicine.
Rosemary contains various chemical compounds, including essential oils, flavonoids, phenols, but diterpenes and triterpenes deserve special attention.
Coordination of biological processes

Coordination of biological processes

Rosemary is known for its antioxidant [ 1], antibacterial [ 2], anti-inflammatory [ 3] and stimulant properties.
It is also being studied for its potential health benefits, such as improving memory and concentration, supporting the digestive system and stimulating blood circulation, as well as anti-diabetic effects [ 4]
Science is increasingly proving that rosemary has extraordinary therapeutic properties, in particular anti-cancer and anti-parasitic properties [ 5].  According to research, rosemary owes these latter properties mainly to carnosol, norursa and norolean.


Carnosol is a diterpene. It has gained attention in the scientific community for its amazing properties and potential health benefits. Over the past few years, several hundred studies have been conducted and documented on its extraordinary benefits. [ 6]
A fascinating property of carnosol is its potential anti-cancer effect. Many studies suggest that carnosol may have the ability to inhibit the growth, induce apoptosis or death of a cancer cell. [ 7] This makes carnosol a promising compound for developing new methods of treating cancer and reducing the risk of cancer. [ 8] Combining carnosol with traditional anticancer therapies may increase their effectiveness, opening the possibility for new treatment strategies.
There are numerous examples of the effectiveness of carnosol in studies on the prevention of oncological diseases.
For example, it brought positive effects in in vitro (on cells) and in vivo (on animals) tests for the following ailments:
- prostate cancer [ 9],
- breast cancer [ 10],
- osteosarcoma / osteosarcoma (Latin: osteosarcoma) [ 11],
- colon cancer [ 12],
- skin cancer [ 13],
- and many others.
It was also noted that carnosol attenuated muscle atrophy and fat lipolysis induced by cancer cachexia. [ 14]
Carnosol - inhibits the production of inflammatory molecules in the body

Carnosol - inhibits the production of inflammatory molecules in the body

In addition to the above-mentioned properties, carnosol has been shown to be a powerful antioxidant, capable of neutralizing free radicals and reducing oxidative cell damage. This makes it a valuable compound for promoting overall health and preventing various chronic diseases. [ 15] Thanks to its antioxidant properties, carnosol is a molecule that improves life expectancy. [ 16] Including carnosol in your diet may support heart health, improve cognitive function, and strengthen the immune system. [ 17]
The study also showed that carnosol inhibits the production of inflammatory molecules in the body, helping to reduce inflammation and protect against chronic disease. [ 18] The antimicrobial properties of carnosol make it a valuable ingredient in skin care products, potentially helping fight a variety of skin diseases caused by bacteria. [ 19] Research also suggests the effective use of carnosol in promoting faster and more effective wound healing. [ 20]
Taken together, the properties of carnosol make it an extraordinary compound with a wide range of potential health benefits. [ 21] Carnosol is a valuable compound that brings great hopes for the future, especially in therapies supporting the fight against cancer.


Norursa and norolean are triterpenes. These are molecules discovered only a few years ago and the world of science is just starting to look at them. They are found in abundance in plants, which contain powerful antibacterial, antidiabetic, antioxidant and anticancer activities. Science is conducting more and more in vitro tests on the extracts of these plants with surprising results.
Ochradenus arabicus, a plant containing norursa and norolean in high quantity, has been noticed by scientists for its various biological activities including antibacterial, antimalarial, anti-inflammatory and even anticancer, antimicrobial, antidiabetic, phenolic, allopathic, antioxidant and nutritional properties.
Tested samples from the stem of Ochradenus arabicus showed maximum potential in the treatment of diabetes. [ 22] However, the flower of this plant from the same sample showed the highest potential to scavenge free radicals. [ 23]
Strong anti-cancer properties

Strong anti-cancer properties

High content of noursa and noroleans was also shown by phytochemical analyzes of the Boswellia papyrifera plant [ 24], as well as in Boswellia carterii and Boswellia serrata [ 25]. The resins from these plants have strong anti-cancer properties, which has been documented by numerous studies. [ 26]
Those conducting this research suggest the need for a more thorough analysis of these biological components, as they could be effective in the production of innovative drugs and other therapeutic agents. Rosemary also has high levels of noursa and norolean.
In addition, studies on rosemary have shown that triterpenoids of the norursan type also have anti-inflammatory properties. [ 27]
As research shows, these compounds have a strong inhibitory effect on the production of nitric oxide (NO) in lipopolysaccharide-activated RAW 264.7 cells. Nitric oxide and its metabolites are mutagens that can cause DNA deamination and inactivate enzymes responsible for repairing damaged DNA chains. Compounds that inhibit NO production or lower its level in the cell may therefore play an important role in the chemoprevention of cancer diseases.
These recently discovered carnosolic acid triterpenes have significant potential to inhibit microbial immunity to overcome microbial infections, neutralize free radicals to prevent cell damage, and also have promising abilities to act as an anticancer agent.


Carnosol (and the carnosol isomer), norursa and noroleana are molecules that are found in high levels in Magavena's DiSole. It is a supplement/bioattractor made from rosemary from special organic crops. Thanks to the proprietary extraction method, DiSole has these active molecules with high bioavailability. This means that the body absorbs them very easily, assimilates them and transforms them into an active form.
Before consuming DiSOLE, read the product leaflet. If there are numerous parasites and microorganisms in our body, nausea, pain and dizziness may occur after consuming DiSOLE. This is due to the release of toxins by parasites when they die and are excreted from the body. This is a temporary symptom and is not a side effect caused by taking DiSOLE, but a natural effect in the process of detoxification and excretion of toxins.
It is worth emphasizing that DiSole is not a medicine. It is a supplement/bioattractor that helps in the processes of self-healing, self-regulation of the body and restoring homeostasis.


[1] https://pubmed.ncbi.nlm.nih.gov/25002023
[2] https://pubmed.ncbi.nlm.nih.gov/30621719
[3] https://pubmed.ncbi.nlm.nih.gov/30287195
[4] https://pubmed.ncbi.nlm.nih.gov/33016104
[5] https://pubmed.ncbi.nlm.nih.gov/33016104
[6] https://www.sciencedirect.com/topics/medicine-and-dentistry/carnosol
[7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600884
[8] https://pubmed.ncbi.nlm.nih.gov/28412913
[9] https://pubmed.ncbi.nlm.nih.gov/18286356 https://pubmed.ncbi.nlm.nih.gov/20736335
[10] https://www.frontiersin.org/articles/10.3389/fonc.2019.00743/full
[11] https://pubmed.ncbi.nlm.nih.gov/29121803
[12] https://pubmed.ncbi.nlm.nih.gov/24481553
[13] https://www.nature.com/articles/s41598-018-22029-x
[14] https://pubmed.ncbi.nlm.nih.gov/33951335
[15] https://pubmed.ncbi.nlm.nih.gov/14688281
[16] https://www.hindawi.com/journals/omcl/2019/5958043
[17] https://www.hindawi.com/journals/omcl/2019/5958043
[18] https://pubmed.ncbi.nlm.nih.gov/21382660
[19] https://pubmed.ncbi.nlm.nih.gov/36978928
[20] https://pubmed.ncbi.nlm.nih.gov/22173778
[21] https://www.sciencedirect.com/science/article/abs/pii/S030438351100067X
[22] https://www.mdpi.com/1420-3049/27/16/5197
[23] https://www.mdpi.com/1420-3049/27/16/5197
[24] https://www.researchgate.net/publication/273210146_Comparative_Phytochemical_Analyses_of_Resins_of_...
[25] https://journals.sagepub.com/doi/pdf/10.1177/1934578X0700200206
[26] https://www.sciencedirect.com/science/article/abs/pii/S2210803319300600
[27] https://www.sciencedirect.com/science/article/abs/pii/S0367326X2100157X